The prevalence and pattern of self-medication with antibiotics among undergraduates of Abia State Polytechnic, Aba Abia State Nigeria was evaluated using structured self-medication administered questionnaire. A total of 350 questionnaires were randomly distributed based on departments with respondent rate of 302(86.29%). Majority of respondents 201(66.56%) were aged between 26 and above, while 99(32.78%) were males and 203(67.22%) were female. Distribution of respondents by department showed they were mainly from Microbiology 98(94.23%), Computer Science 35(87.5%) and Banking and Finance 38(84.21%) respondents. 263(87.09%) respondents admitted they self medicate. The major reasons given for self medication with antibiotics were assumed knowledge on antibiotics 161(53.31%), prior experience on use 42(13.91%), financial constraints 34(11.26%), while others admitted to lack of time to go for consultation (10.60%). Majority of respondents 220(72.85%) however, self medicate with antibiotics frequently. The most reported antibiotics used was Amoxicillin 142(47.02%), followed by Ciprofloxacin (a fluoroquinone) 68(22.52%). The condition for which antibiotics were taken included fever 102(33.78%), headache and other pains 80(26.49%). More than half of the respondents 168(55.63%) purchase the drugs from private pharmacies. These findings highlight the need for planning interventions to promote the judicious use of antibiotics among the student population and indeed the Nigerian populace.